Abstract Library

#2204 Pancreatic Neuroendocrine Tumors: Analysis of Prognostic Factors After Surgical Resection in a Single Centre

Introduction: Pancreatic neuroendocrine tumors (PNET) are rare, heterogeneous and challenging neoplasms. Surgical resection is the only curative treatment. Recurrence can occur even after years. Diagnosis of malignancy is difficult so further studies are necessary to identify prognostic criteria.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Blanco L, Dopazo C, Pando E, Caralt M, Puértolas N,

Keywords: PNETS, Prognosis,

#1474 Curative Resection in Digestive Neuroendocrine Neoplasms: Recurrence-free Survival Rate and Definition of a Risk Score for Recurrence

Introduction: Surgery with radical intent is the only curative option for digestive neuroendocrine neoplasms (DNENs), but clinical practice shows disease-free pts recurring even after years

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Merola E, Pascher A, Denecke T, Arsenic R, Wiedenmann B,

Keywords: neuroendocrine, curative surgery, recurrence risk,

#756 Evaluation of VEGF, VEGFR 1-2-3 and Endocan/ESM-1 Expression in Gastroenteropancreatic Neuroendocrine Tumors and Correlation with Ki-67 Labeling and Prognosis

Introduction: Angiogenesis is recognized to play a critical role in progressive tumor growth and spreading and its inhibition is a valuable approach to cancer treatment. Markers of angiogenesis include assessment of microvessel density on tissue sections (often evaluated with antibodies against pan-endothelial antigens, such as CD34) and expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR 1-2-3). Endocan, also called endothelial cell specific molecule-1 (ESM-1), has been shown to be expressed by endothelial tumor cells and especially by tip cells during angiogenesis. Endocan is highly up-regulated by pro-angiogenic molecules, such as VEGF. Recently, Endocan has been identified to be one of the molecules involved in the switch from dormant to fast-growing tumors. Among endocrine tumors, Endocan expression has been evaluated only in pituitary adenomas: a positive association between endothelial Endocan expression and recurrence risk, tumor size, tumoral invasion and average mitosis count has been demonstrated. In contrast, there was no association between endothelial Endocan expression and the Ki-67 labeling index

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Lugli F, Iacovazzo D, Fusco A, Lanza P, Rindi G,

Keywords: endocan, angiogenesis, vegf,